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Dr Eithne Costello

Eithne CostelloResearch Institution: University of Liverpool

Award: £180,000  Duration: 3 years

Project Title: Preclinical evaluation of Nrf2 inhibition as a means to improve chemotherapeutic efficacy in patients with pancreatic cancer

Project Aims: Dr Costello and her colleagues aim to unravel how pancreatic tumour cells use the protein Nrf2 to protect themselves against chemotherapeutic drugs. Pancreatic cancer cells have high levels of this protein, and respond to chemotherapy by producing even more - effectively becoming resistant to treatment.  The team aims to find ways to block Nrf2 that enables the cancer drugs to work more effectively as treatments.