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Professor Laura Itzhaki

Professor Laura ItzhakiResearch Institution: University of Cambridge

Award: £200,000   Duration: 3 years

Project Title: A new approach to drugging intractable targets for the treatment of pancreatic cancer

Project Aims: Cells stay healthy by tagging faulty proteins with a molecule called ubiquitin that acts lile an address label, sending the proteins to be destroyed by the cell's waste-disposal machinery. Professor Itzhaki has developed a technology that mimics this process, forcing ubiquitin to attach to selected proteins and trigger their destruction. This project will test if the technology can eliminate proteins produced by a faulty gene called KRAS, which is found in many pancreatic cancers.