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Professor Yaohe Wang

Professor Yaohe WangResearch Institution: Barts Cancer Institute, Queen Mary University of London

Award: £200,000   Duration: 30 months

Project Title: Identification and characterisation of neoantigens of pancreatic cancer patients for development of a personalised T cell receptor-based adoptive T cell transfer therapy

Project Aims: Prof Wang has analysed the tiny genetic differences between healthy cells and cancer cells in 100 pancreatic cancer patients. These ‘markers’ are what the immune system looks for in order to attack cancer. This project will design immune cells that can specifically attack cells displaying different markers. If successful, this could lead to a personalised treatment for pancreatic cancer, in which these immune cells are matched with the markers displayed by individual patients’ tumours, and infused into the patient to attack the cancer.