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Research supported by Pancreatic Cancer Research Fund

All the research we support is funded entirely by public donations.


To date, fifty-nine projects have been funded, with a total value of £9.2 million. These are focused on early diagnosis of pancreatic cancer and the development and monitoring of more effective treatments.

 

Grants made in 2018 Award Round - £1.2 milion

 
Drv Richard Clarkson 

Principal Applicant: Dr Richard Clarkson
Institution: Cardiff University

Project Title: Unlocking oncogene dependent cell death in pancreatic tumours
More information

Professor Gunnel Hallden 

Principal Applicant: Dr Gunnel Halldén
Institution: Barts Cancer Institute, QMUL

Project Title: Identification of drugs that promote activation of the host anti-cancer immune responses through enhancement of virus-mediated cell lysis
More information

 Prof Laura Itzhaki

Principal Applicant: Professor Laura Itzhaki
Institution: University of Cambridge

Project Title: A new approach to drugging intractable targets for the treatment of pancreatic cancer
More information

 Professor Hemant Kocher

Principal Applicant: Professor Hemant Kocher
Institution: Barts Cancer Institute, QMUL

Project Title: The role of T-cells within tertiary lymphoid structures of pancreatic ductal adenocarcinoma
More information

Prof Maeve Lowery 

Principal Applicant: Professor Maeve Lowery
Institution: Trinity College Dublin

Project Title: Identification of coding and novel regulatory mutations in DNA Damage Response Pathway genes as personalised targets for the treatment of patients with pancreatic cancer  More information

 Dr Naomi Walsh

Principal Applicant: Dr Naomi Walsh
Institution: Dublin City University

Project Title:
Pancreatic cancer stem cell targeted delivery of 5-FU to overcome drug resistance
More information

 Dr Laura Woods

Principal Applicant: Dr Laura Woods
Institution: London School,of Hygiene and Tropical Medicine

Project Title: Developing a risk score for pancreatic cancer diagnosis using machine learning techniques applied to linked routine data   More information

 

Grants made in 2017 Award Round - £1.1 million

Dr Angus Cameron 

Principal Applicant: Dr Angus Cameron
Institution: Barts Cancer Institute, QMUL

Project Title: Targeting pancreatic stellate cell activation to direct new therapeutic strategies for pancreatic ductal adenocarcinoma  More information 

Dr Bart Cornelissen  Principal Applicant: Dr Bart Cornelissen
Institution: University of Oxford

 
Project Title: PARP molecular imaging in pancreatic cancer (PARP-PET in PDAC)
More information

 Professor Peter Friend

Principal Applicant: Professor Peter Friend
Institution: University of Oxford 

Project Title: High Intensity Focused Ultrasound for treatment of Pancreatic Cancers. A Clinical Pilot study
More information 

 Professor John Marshall Principal Applicant: Professor John Marshall
Institution: Barts Cancer Institute, QMUL
 

Project Title: Does cancer cell integrin αvβ8 promote pancreatic adenocarcinoma and represent a novel therapeutic target   More information 

 Dr Mairead McNamara

Principal Applicant: Dr Mairéad McNamara
Institution: University of Manchester/The Christie NHS Foundation Trust

Project Title: A study to assess the feasibility of evaluating BRCAness in plasma and tumour samples from patients with advanced pancreatic adenocarcinoma   More information

 Prof Yaohe Wang

Principal Applicant: Professor Yaohe Wang
Institution: Barts Cancer Institute, QMUL

Project Title: Identification and characterisation of neoantigens of pancreatic cancer patients for development of a personalised T cell receptor-based adoptive T cell transfer therapy   More information

Dr Claire Wells 

Principal Applicant: Dr. Claire Wells
Institution: King's College London

Project Title: Validation of the PAK4:PI3K nexus as a therapeutic target in pancreatic cancer 
More information

 

Grants made in 2016 Award Round 

 Professor Alex Breeze

Principal Applicant: Professor Alex Breeze
Institution: University of Leeds

Project Title: Allosteric inhibitors of the Ras-activating exchange factor SOS
More information...  

 Professor John Callan

Principal Applicant: Professor John Callan
Institution: Ulster University

Project Title: Improving tumour oxygenation to enhance the combined sonodynamic and radiotherapy treatment of pancreatic cancer More information...  

 Dr Tanja Crnogorac-Jurcevic

Principal Applicant: Dr Tanja Crnogorac-Jurcevic
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Developing biomarker panel score for urine testing for early pancreas cancer detection 
More information.. 

Professor John Marshall 

Principal Applicant: Professor John F. Marshall
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Development of a new peptide-drug conjugate for treating αvβ6-positive pancreatic ductal adenocarcinoma (PDAC) More information...

Dr Sarah McClelland 

Principal Applicant: Dr Sarah McClelland
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Identifying mechanisms driving chromosomal instability in pancreatic cancer
More information...

 

 Grants made in 2015 Award Round

Dr Bart Cornelissen 

Principal Applicant: Dr Bart Cornelissen
Institution: University of Oxford

Project Title: Imaging pancreatic cancer, targeting claudin-4 in tight junctions More information

 Eithne Costello

Principal Applicant: Dr Eithne Costello
Institution: University of Liverpool

Project Title: Preclinical evaluation of Nrf2 inhibition as a means to improve chemotherapeutic efficacy in patients with pancreatic cancer More information

 Fieke Froeling

Principal Applicant: Dr Fieke Froeling
Institution: Imperial College London

Project Title: Novel strategies for pancreatic cancer treatment: an epigenetic approach More information

 Claus Jorgensen

Principal Applicant: Dr Claus Jorgensen
Institution: Cancer Research UK Manchester Institute, University of Manchester

Project Title: Targeting enzymes for stromal normalisation in pancreatic ductal adenocarcinoma More information

Venkat Kanamarlapudi 

Principal Applicant: Prof Venkat Kanamarlapudi
Institution: Swansea University

Project Title: Investigation of IL-13Rα2 targeted therapy for pancreatic cancer More information

 Patricia Sancho

Principal Applicant: Dr Patricia Sancho
Institution: Barts Cancer Institute, Queen Mary University of London 

Project Title: Targeting mitochondrial metabolism as the Achilles heel of cancer stem cells
More information

 

 Grants made in 2014 Award Round

 Jason Bruce

Principal Applicant: Dr Jason Bruce
Institution: University of Manchester

Project Title: Fuelling the calcium pumps in pancreatic cancer: strategy for cell survival or 'Achilles heel'?
More information...
Watch the video

 Patrick Forde

Principal Applicant: Dr Patrick Forde
Institution: Cork Cancer Research Centre, University College Cork

Project Title: Harnessing the immune system to target primary and secondary pancreatic cancer
More information...
Watch the video

 Stephanie Kermorgant

Principal Applicant: Dr Stephanie Kermorgant
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Understanding and targeting c-Met endosomal signalling in pancreatic cancer
More information..

 Hemant Kocher

Principal Applicants: Prof Hemant Kocher/Dr Richard Grose
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Development of FGFR signalling pathway targeted therapies for pancreatic cancer
More information...

 Laura Machesky

Principal Applicant: Prof Laura Machesky
Institution: CRUK Beatson Institute, Glasgow

Project Title: Development of new therapies against metastasis of pancreatic cancer
More information

 Michael Schmid

Principal Applicant: Dr Michael Schmid
Institution: University of Liverpool

Project Title: Role of monocytes in the metastatic process: identification of novel molecular targets to fight pancreatic cancer
More information...

 Yaohe Wang

Principal Applicant: Dr Yaohe Wang
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Development of a novel prime-boost vaccination regime for treatment of pancreatic cancer
More Information...

 

 Grants made in 2012 Award Round

Professor Caroline Dive

Principal Applicant: Professor Caroline Dive
Institution: Paterson Institute for Cancer Research

Project Title: Development of blood-borne biomarkers for improving treatment selection for pancreatic cancer patients More information...
Watch the video

Professor Lindy Durrant

Pricipal Applicant: Professor Lindy Durrant
Institution:
The University of Nottingham

Project Title: Characterisation of novel anti-glycan mAbs targeting pancreatic cancer More information...

   
Dr John Marshall

Principal Applicant: Dr. John Marshall
Institution: Centre for Tumour Biology, Barts Cancer Institute 

Project Title: Using Transgenic Mouse Models to Develop Integrin avb6-Targeted Therapy of Pancreatic Cancer More information...

Dr Stephen Pereira

Principal Applicant: Dr. Stephen Pereira
Institution: UCL Institute of Hepatology

Project Title: Targeting tumour metabolomics: a novel strategy for the diagnosis and treatment of pancreatic carcinoma More information...
Watch the video

Dr Yaohe Wang

Principal Applicant: Dr. Yaohe Wang
Institution: Barts Cancer Institute

Project Title: Development of a Novel Therapy for Pancreatic Cancer using Lister Strain Vaccinia Virus Armed with a Hypoxia-Regulated Immunostimulatory Gene, Interleukin-12 More information...

 

 Grants made in 2011 Award Round

 Eithne Costello

Principal Applicant: Dr. Eithne Costello
Institution: University of Liverpool

Project Title: Involvement of microRNAs in the activation of cancer-associated pancreatic stellate cells. More information...

 Prof Marco Falasca

Principal Applicant: Professor Marco Falasca
Institution: Blizard Institute of Cell and Molecular Science, Barts and The London 

Project Title: ABC transporters autocrine loop inhibition to treat pancreatic cancer. More information...

 Gunnel Hallden


Principal Applicant: Dr. Gunnel Halldén
Institution: Centre for Molecular Oncology and Imaging, Barts Cancer Institute

Project Title: Improved virotherapy for integrin-expressing pancreatic cancers. More information...

 Prof Nick Lemoine


Principal Applicant: Professor Nick Lemoine
Institution: Barts Cancer Institute, Queen Mary University of London

Project Title: Evaluation of the role of ΔNp63α in a new transgenic mouse model that mimics a highly aggressive subtype of human pancreatic cancer. More information...   
Watch the video

Prof Stephen Neidle


Principal Applicant:
Professor Stephen Neidle
Institution: The School of Pharmacy, University of London

Project Title: The design and development of novel agents for the treatment of chemoresistant pancreatic cancer. More information...
Watch the video...

 

Grants made in 2010 Award Round

Professor Marco Falasca

Principal Applicant: Professor Marco Falasca
Institution: Blizard Institute of Cell and Molecular Science, Barts and The London

Project Title: Identification of potential novel therapeutic agents for pancreatic cancer. 

 Professor Anthony Magee Principal Applicant: Professor Anthony Magee
Institution:Imperial College London


Project Title:
 Hedgehog acyltransferase: a potential therapeutic target in pancreatic cancer. More information...
Watch the video...

 Professor Jeff Evans

Principal Applicant: Professor Jeff Evans
Institution: University of Glasgow

Project Title: In vivo evaluation of Src kinase inhibition as adjuvant therapy following pancreatic cancer resection. More information...
Watch the video...

 

 

 Dr. Claire Wells

Principal Applicant: Dr Claire Wells
Institution: Kings College London

Project Title: PAK family kinases in pancreatic cancer – a study of therapeutic potential. More information...
Watch the video...

 

Grants made in 2009 Award Round

Dr. Gunnel Hallden

Principal Applicant: Dr. Gunnel Halldén
Institution: Centre for Molecular Oncology and Imaging, Barts Cancer Institute

Project Title: Targeting pancreatic cancer with oncolytic virotherapy and cytotoxic drugs. More information... 
Watch the video...

Mr. Hemant Kocher

Principal Applicant: Mr. Hemant Kocher
Institution: Centre for Tumour Biology, Barts Cancer Institute

Project Title: FGF Signalling in pancreatic cancer. More information... 
Watch the video...

Professor Lindy Durrant

Principal Applicant: Professor Lindy Durrant
Institution: University of Nottingham, Academic Clinical Oncology

Project Title: Glycolipids as targets for therapeutic anti-tumour monoclonal antibodies for treatment of pancreatic cancer. More information... 
Watch the video...

Dr. Yaohe Wang

Principal Applicant: Dr. Yaohe Wang
Institution: Centre for Molecular Oncolgy and Imaging, Barts Cancer Institute

Project Title: Novel therapy for pancreatic cancer using a Lister strain vaccinia virus armed with Interleukin-10. More information... 
Watch the video...

Professor Marco Falasca

Principal Applicant: Professor Marco Falasca
Institution: Blizard Institute of Cell and Molecular Science, Barts and The London

Project Title: Investigation of mechanisms regulating phosphoinositide 3-kinase expression in pancreatic cancer. More information...
Watch the video...

 

Grants made in 2008 Award Round

Dr. Tanja Crnogorac-Jurcevic

Principal Applicant: Dr. Tatjana Crnogorac-Jurcevic
Institution: Centre for Molecular Oncology and Imaging, Barts Cancer Institute

Project Title: Discovery and validation of urinary peptides for non-invasive diagnosis of pancreatic cancer. More information... 
Watch the video...

Dr. Azeem Saleem

Principal Applicant: Dr. Azeem Saleem
Institution: University of Manchester, Academic Radiation Oncology

Project Title: Pilot study to evaluate the pathological basis and utility of FLT-PET/CT and FDG-PET/CT in therapy development in pancreatic cancer. More information... 
Watch the video...

Dr. John Marshall

Principal Applicant: Dr. John Marshall
Institution: Centre for Tumour Biology, Barts Cancer Institute  

Project Title: Development of imaging and therapy of pancreatic cancer by targeting the integrin αvβ6. More information...
Watch the video...

Professor Marco Falasca

Principal Applicant: Professor Marco Falasca
Institution: Blizard Institute of Cell and Molecular Science, Barts and The London

Project Title: Role of phosphoinositide 3-kinase class ΙB in human pancreatic cancer. More information... 
Watch the video...

 

Grants made in 2007 Award Round

Dr. Eithne Costello

Principal Applicant: Dr. Eithne Costello
Institution: University of Liverpool - Division of Surgery & Oncology

Project Title: Crosstalk between pancreatic cancer cells and tumour infiltrating monocytes: role in invasion and potential for therapeutic exploitation. More information... 
Watch the video...

 

Grants made in 2006 Award Round

Dr. Tatjana Crnogorac-Jurcevic

Principal Applicant: Dr. Tatjana Crnogorac-Jurcevic
Institution: Centre for Molecular Oncology and Imaging, Barts Cancer Institute

Project Title: The role of S100PBPR in early pancreatic cancer development. More information...