Project Title: Preclinical evaluation of Nrf2 inhibition as a means
to improve chemotherapeutic efficacy
in patients with pancreatic cancer
Project Aims: Dr Costello and her colleagues aim to unravel how pancreatic tumour cells use the protein Nrf2 to protect themselves against chemotherapeutic drugs. Pancreatic cancer cells have high levels of this protein, and respond to chemotherapy by producing even more – effectively becoming resistant to treatment. The team aims to find ways to block Nrf2 that enables the cancer drugs to work more effectively as treatments.