Project Title: Identifying mechanisms driving chromosomal
instability in pancreatic cancer
Project Aims: Pancreatic cancer cells display ‘chromosomal instability’, a defect that involves some of the cells’ genetic material – chromosomes – being deleted or rearranged during cell division. This instability makes tumours hard to treat, but the reasons for this are poorly understood. Dr McClelland will investigate and analyse the possible causes of chromosomal instability in pancreatic cancer to see whether efforts to limit this defect before administering chemotherapy will improve patients’ response to treatment.