Project title: A new approach to drugging intractable targets
for the treatment of pancreatic cancer
Project aims: Cells stay healthy by tagging faulty proteins with a molecule called ubiquitin that acts like an address label, sending the proteins to be destroyed by the cell’s waste-disposal machinery. Prof Itzhaki has developed a technology that mimics this process, forcing ubiquitin to attach to selected proteins and trigger their destruction. This project will test if the technology can eliminate proteins produced by a faulty gene called KRAS, which is found in many pancreatic cancers.