Researching the cures


Dr Richard Clarkson

Dr Clarkson's research focuses on c-FLIP, a molecule found in pancreatic cancer cells that stops damaged or diseased cells from dying.

Project title: Unlocking oncogene dependent cell death in pancreatic tumours

Project aims: Normal cells are programmed to die if they become damaged or diseased in a process called apoptosis, but pancreatic cancer cells contain a molecule called c-FLIP which stalls this process. Dr Clarkson has shown in laboratory tests that blocking c-FLIP from working ‘releases the brakes’ on the anti-tumour process. He now wants to see if this works in mice with pancreatic tumours and will test new ways to block c-FLIP.