Researching the cures


Professor Len Seymour

Professor Seymour’s project aims to develop a virus that will specifically infect and break down pancreatic cancer cells and activate the immune system to help kill the cancer. Immunotherapy has made slow progress to date in pancreatic cancer, but Prof Seymour’s approach unusually targets both the tumour itself and the thick protective coating (the stroma) which surrounds the tumour. He hopes that this potential treatment could ultimately be delivered intravenously, which would benefit patients whose cancer has already spread to lymph nodes and other organs beyond the pancreas.

Project Title: Targeting immunotherapy to the pancreatic tumour microenvironment using oncolytic viruses to direct T cell cytotoxicity to stress-induced ligands