Project title: Development of an enhanced oncolytic Vaccinia virus-based therapeutic regime that simultaneously targets multiple elements of the tumour promoting microenvironment in pancreatic cancer.
Professor Yaohe Wang
In previous PCRF-funded research Professor Wang successfully modified a virus that was shown to be effective in killing pancreatic cancer cells in laboratory tests. But we now know that the cancer has many different ways to evade treatment and become resistant to ‘virotherapy’. Professor Wang is using the latest knowledge to design a new virotherapy that targets pancreatic cancer’s multiple resistance mechanisms at the same time, to both kill the cells and prevent them from returning.